Calbrex

Anti-âge Complex

Anti-âge Complex

Calbrex-i

Calbrex-i

Calbrex

The comprehensive advanced supplement to regenerate your dog's joint cartilage.

The joint cartilage, like all body parts, regularly renews itself. Calbrex™ can effectively stimulate this natural regeneration process with a combination of active compounds that boost the cartilage metabolism. Calbrex™ increases the synovial viscosity and strongly stimulates cartilage renewal activity. It can significantly improve the joint cartilage structure in 12 to 24 weeks*. Calbrex™ is clinically proven to promote the growth of new cartilage tissue and can turn back the clock for your dog's damaged joints.

(*) The sooner the joint condition is taken care of, the faster the results will appear.

SKU#:  78368
Powder 150 gr
IN STOCK
$59.00

PRODUCT FACTS

Daily serving: 5 gr (for 45 lbs dog) / Servings per container: 30

Amount per serving
BCP Collagen Peptides - Clinical Potency Bioactives Special Dogs
3000 mg
Orthosilicic acid - High absorption non-crystallized silica
300 mg
Eggshell Membrane NEM® with glycosaminoglycans mix
200 mg
Hyaluronic Acid Complex HJ (High/Very High molecular weight HA complex with validated absorption)
30 mg
MSM (Methylsulfonylmethane)
500 mg
Curcumin C3 Complex® - Curcuma longa rhizome std. to 95% - natural ratio curcuminoids (76:19:5)
125 mg
Mucopolysaccharides - Chondroitin sulfate LMW Pharmagrade (molecular weight: 3 - 16 kD) & Glucosamine Hcl
150 mg
Harpogophytum Procumbens Std. to 5% Harpagosides
200 mg
Omega-3 fish oil 18/12 (EPA 150 mg + DHA 100 mg)
250 mg
Manganese Pidolate
1.7 mg
Vitamin C
100 mg
Bioperine ®
2 mg
Other ingrédients: Chicken flavor.

DIRECTIONS

To be mixed to your pet’s food. Add the powder quanitty that fits your dog size according to the chart given. Use daily without interruption and over several months.

PRODUCT DETAILS


Bioactive Collagen HP-BCP Special Pets

The most effective form of collagen for joints adapted to dogs digestive system

Collagen HP-BCP is the best known form of collagen for joint health and it has been extensively studied in different clinical trials. Because dogs digestive system differs from humans, specific adjustments were made to ensure a high rate of absorption at the gut level. HP-BCP Pets is proven to enhance the joint renewal metabolism and stimulate the growth of new cartilage tissue in dogs. HP-BCP Pets is well absorbed and it concentrates in the joints where it has a significant impact on specific cells within the cartilage that are responsible for regularly producing new cartilage components. These cells, called chondrocytes, will increase their synthesis of collagen and proteoglycans, which together represent 95% of the cartilage structure.

Knee Cartilage Histological Section

A study by the Collagen Research Institute in Kiel, Germany, showed that HP-BCP accumulates in joint tissue and stimulates cell biosynthesis to produce collagen and proteoglycans. After 3 months of therapy, a significant change in formerly degraded cartilage is visible. Compared to joint cartilage with no treatment (left side), the joint cartilage appears supple, smooth and full in appearance.

(Orally administered collagen hydrolysate halts the progression of osteoarthritis in STR/ort MICE. Oesser S et al.(2007) Osteoarthritis Cartilage 15:C61-C62,94)

Magnetic Resonance Imaging

The study conducted at Tufts Medical Center and Harvard Medical School and presented at the OARSI congress (Osteoarthritis Research Society International) showed that oral intake of HP-BCP provides clear improvement in human cartilage, for the first time measured using MRI (Magnetic Resonance Imaging) technology.

(Change in knee osteoarthritis cartilage detected by delayed gadolinium enhanced magnetic resonance imaging following treatment with collagen hydrolysate: a pilot randomized controlled trial. McAlindon and Al. (2011) Osteoarthritis and Cartilage Volume 19, Issue 4, April 2011, Pages 399-405)

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Hyaluronic Acid Complex HJ

Restoring and maintaining quality synovial fluid

articular synovial fluid

To perform well, joints need lubrication and this is why there is a thick viscoelastic substance called the synovial fluid inside the joint capsule. What confers this fluid its remarkable properties is Hyaluronic Acid (HA), a molecule that has the ability to hold up 1000 times its weight in water. HA forms large viscoelastic gels that reduce friction between cartilage surfaces and protects them.

Arthritic joints have a much lower concentration of HA than normal joints and restoring adequate HA levels is an important part of joint health. The Hyaluronic Complex HJ is a unique patented natural ingredient with a high content of sodium hyaluronate as a mix of High/Very High molecular weight Hyaluronic Acid. HA is the chief component of synovial fluid and its usefulness has been proven in numerous clinical trials.

Low Molecular Weight Hyaluronic Acid (LMW-HA) is sometimes touted as a better HA because it allows for a better intestinal absorption. But scientific evidence shows that HA is only safe and beneficial in its High Molecular Weight form (HMW-HA). Research has revealed that LMW-HA can be harmful as it promotes inflammation and has other negative side effects. On the other hand HMW-HA is much more effective at retaining water and its rate of absorption is significant enough to accumulate in the joint cavity.

The uptake of high quality HA in the joints improves lubrication, reduces inflammation and slows down the degradation process. The cartilage is also better nourished, it helps the cartilage nenewal and it can significantly improve joint flexibility.

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MSM (Methylsulfonylmethane)

Research has observed that the sulfur content of cartilage decreases with age, and that this decrease parallels degeneration in the joints. A study has clearly shown that arthritic joints have sulfur levels three times lower than healthy ones. Sulfur is necessary for making collagen, the primary constituent of cartilage and connective tissue.

MSM is a bioavailable natural form of organic sulfur found in all living organisms. It is exceptionally well tolerated and it is rated as one of the safest substances in biology. Sulfur is the third most abundant mineral in humans and mamalians, after calcium and phosphorous. There is a general assumption that sulfur requirement is met with adequate protein intake which provides the amino acids methionine and cysteine, but disfunctions in methionine metabolism could induce sulfur deficiencies.

MSM is very helpful for joint metabolism. Even severe cases of joint alteration can benefit from MSM supplementation as it is able to significantly improve chronic pain without any side effects. Aside from its anti-inflammatory action MSM can also stimulate the the immune system and improve the internal production of Glutathione, the body's major own antioxidant.

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Eggshell Membrane NEM®

Eggshell Membrane NEM®is a food-sourced ingredient derived from the membrane of an eggshell. It supplies essential nutrients needed to support joint mobility and the healthy production of cartilage and connective tissue. It is a unique biological matrix proven bioavailable and effective.Double-blind, placebo-controlled and open-label trials have all showcased an increase in joint comfort, flexibility, and increased range of motion. Published human studies have shown beneficial results in 7-10 days.


After 30 days intake:

  • 72.5% improvement in general pain.

  • 43.7% improvement in flexion range of motion.


ESM appears to supply the building blocks in a pattern that stimulates the healing process for the joint and promote cartilage renewal.

Mucopolysaccharides

Chondroitin sulfate LMW Pharmagrade & Glucosamine Hcl

Glucosamine and Chondroitin are the most popular substances and most widely used ingredients in joint health products. Clinical studies are numerous but results are unclear and differ widely. After years of research, it is still difficult to precisely assess their level of efficacy but they no longer appear to be silver bullets as once thought. Nonetheless they can be useful in assisting other active ingredients and help restore functionality faster. There is also data showing that these mucopolysaccharides support the healing process of injured tendons.

It is important to remember that Chondroitin in its basic form it is mostly useless since it is simply not absorbed. The benefits of Chondroitin Sulfate only concerns the pharmagrade CS, a highly purified and depolymerized substance. Conventional food grade chondroitin is a very large molecule that is not assimilated through the intestinal mucosa. The molecular weight of the Chondroitin used has a direct influence upon its level of efficacy. The properties of the low molecular weight Chondroitin do not apply to conventional Chondroitin (Biol. Pharm. bull. 27(1)47-51 - 2004).

Devil's Claw

Harpagophytum procumbens, known as Devil's Claw is traditionnally used for its benefits on the joints and concerns about rheumatic ailments. It relieves pain and inflammation and Its effectiveness is commonly attributed to its identified special active constituents, the "harpagosides". Several clinical trials have shown effectiveness in alleviating pain and it appears to prevent the production of pro-inflammatory cytokines. This result seems derived from its harpagosides content but also from the interaction of several substances contained in its root (1).

Devil's Claw appears to be effective for chronic pain with a notable improvement of symptoms that reaches peak efficacy after a period that ranges from 6 to 8 weeks (2) (3) (4), though some scientific sources cite a 4 months duration to reach maximal efficacy (5).

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Organic Silica

Orthosilicic acid (non-crystalized silica)

Silicon is an essential trace mineral that is naturally present in the human body. It play a major role in bone strength, healthy skin and nails and cartilage formation. Studies have shown that a silicon deficient diet produces aberrant metabolism of the bone and connective tissue leading to structural abnormalities of the articular cartilage with small and poorly formed joints. It was later discovered that silicon deprivation decreases collagen formation in wound healing as well as bone formation.*

Silicon is widely available and abundant in nature but its bioavailability is very poor. It is an extremely unstable compound that crystalizes very quickly forming an insoluble inert substance. Its absorption is drastically low and it can’t be utilized by the human organism.

Calbrex™ contains a stable high absorption form of dietary silicon. It is an ortho-silicic acid molecule stabilized in maltodextrin. It is stabilized by a proprietary method that inhibits the polymerization of ortho-silicic acid, keeping the molecule stable and increasing its bioavailability in the body.

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Curcumin

The ongoing studies conducted on the miracle spice from India keep confirming its usefulness for an ever wider range of health concerns. And Turmeric is also helpful for arthritis and other joint problems through its modulation of inflammatory signals in several different ways. Its active component, Curcumin, is able to prevent pro-inflammatory messaging, it can reduce the activity of pro-inflammatory enzymes and it can also downregulate the immune system over-reactivity on inflammation areas.

Clinical research on orally administrated curcumin has shown that it is equally or more potent than synthetic anti-inflammatory drugs when taken for several weeks and up to several months. The level of relief demonstrated is in the range of 40 - 60% reduction of symptoms of knee osteoarthritis on threadmill testing.

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REFERENCES:

    Collagen BCP:

  • Oesser, S.; Adam, M., Babel, W. and Seifert, J. (1999). "Oral administration of 14C labelled gelatine hydrolysate leads to an accumulation of radioactivity in cartilage of mice (C57/BL)". Journal of nutrition 129 (10): 1891–1895. PMID 10498764
  • Oesser, S.; Seifert, J. (2003). "Stimulation of type II collagen biosynthesis and secretion in bovine chondrocytes cultured with degraded collagen". Cell tissue research 311 (3): 393–399. doi:10.1007/s00441-003-0702-8. PMID 12658447
  • In-Vivo: A Randomized Double Blind Placebo Clinical Trial Evaluating the Efficacy and Safety of Hyal-Joint® Compared to Placebo for the Improvement of Quality of Life in Adults with Osteoarthritis of the Knee. Kalman et al (2008) Nutrition Journal. 7(3) (http://www.nutritionj.com/content/7/1/3)
  • Comparison of different experimental designs to evaluate of an intervention in osteoarthritis patients. D. Martinez-Puig, C. Chetrit, I. Möller. Osteoarthritis and Cartilage, Volume 19, Supplement 1, September 2011, Page S147
  • Hyaluronic Acid

  • Motohashi et al. Concentration and degradation of hyaluronic acid in knee synovial fluid from carrageenin-induced rabbit arthritis. Chem Pharm Bull (Tokyo). 1990 Jul;38(7):1953-6.
  • Balogh et al. Absorption, uptake and tissue affinity of high-molecular-weight hyaluronan after oral administration in rats and dogs. J Agric Food Chem. 2008 Nov 26;56(22):10582-93.
  • Bellamy et al. Viscosupplementation for the treatment of osteoarthritis of the knee. Database Syst Rev. 2006 Apr 19;(2):CD005321.
  • Eggshell Membrane NEM®

  • Ruff and al. Eggshell membrane: A possible new natural therapeutic for joint and connective tissue disorders. Results from two open-label human clinical studies. Clin Interv Aging. 2009; 4: 235–240.
  • Wedekind et al. Beneficial effects of natural eggshell membrane (NEM) on multiple indices of arthritis in collagen-induced arthritic rats. Modern Rheumatology Volume 27, 2017 - Issue 5 p 838-848
  • Benson et al. Effects of Natural Eggshell Membrane (NEM) on Cytokine Production in Cultures of Peripheral Blood Mononuclear Cells: Increased Suppression of Tumor Necrosis Factor- α Levels After In Vitro Digestion. Journal of medicinal food 15(4):360-8 · December 2011
  • Silicon:

  • E. M. Carlisle, In vivo requirement for silicon in articular cartilage and connective tissue formation in the chick,J. Nutr. 106, 478–484 (1976).
  • E. M. Carlisle, A silicon requirement for normal skull formation in chicks,J. Nutr. 110, 352–359 (1980). https://www.ncbi.nlm.nih.gov/pubmed/1255267?dopt=Abstract
  • Formation in Wounds and Bone, and Ornithine Transaminase Enzyme Activity in Liver C. D. Seaborn and F. H. Nielsen March 1, 2002 https://link.springer.com/article/10.1385/BTER:89:3:251
  • Devil's Claw:

  • 1. Anauate and al. Effect of isolated fractions of Harpagophytum procumbens D.C. (devil's claw) on COX-1, COX-2 activity and nitric oxide production on whole-blood assay. Phytother Res. 2010 Sep;24(9):1365-9. doi: 10.1002/ptr.3124.
  • 2. Chrubasik S, et al. Comparison of outcome measures during treatment with the proprietary Harpagophytum extract doloteffin in patients with pain in the lower back, knee or hip. Phytomedicine. (2002)
  • 3. Chrubasik S, et al. A randomized double-blind pilot study comparing Doloteffin and Vioxx in the treatment of low back pain. Rheumatology (Oxford). (2003)
  • 4. Chrubasik S, et al. A 1-year follow-up after a pilot study with Doloteffin for low back pain. Phytomedicine. (2005)
  • 5. Thanner J, et al. Retrospective evaluation of biopsychosocial determinants and treatment response in patients receiving devil's claw extract (doloteffin). Phytother Res. (2009)
  • Curcumin:

  • Jackson JK, et al. The antioxidants curcumin and quercetin inhibit inflammatory processes associated with arthritis. Inflamm Res. (2006)
  • Ramadan G, Al-Kahtani MA, El-Sayed WM. Anti-inflammatory and anti-oxidant properties of Curcuma longa (turmeric) versus Zingiber officinale (ginger) rhizomes in rat adjuvant-induced arthritis. Inflammation. (2011)
  • Belcaro G, et al. Efficacy and safety of Meriva®, a curcumin-phosphatidylcholine complex, during extended administration in osteoarthritis patients. Altern Med Rev. (2010)
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Subtitle The comprehensive advanced supplement to regenerate your dog's joint cartilage.
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